Protein Details: Gap junction gamma-2 protein

Protein ID

ICDB_Pro_1013

Protein Name

Gap junction gamma-2 protein

Gene Name

GJC2; GJA12

Organism

Homo sapiens (Human)

Length

439 amino acids

AlphaFoldDB

AF-Q5T442-F1-model_v4.pdb

Function

Sequence

MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAKPRAGSEKGSASSRDGKTTVWI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Spastic Paraplegia;Autosomal Recessive and Leukodystrophy;Hypomyelinating

Location

Expressed in central nervous system; in sciatic nerve and sural nerve. Also detected in skeletal muscles.

DOI ID

10.1038/nature04727; 10.1101/gr.2596504; 10.1086/422763; 10.1093/braiwn328; 10.1016/j.ajhg.2010.04.010

RefSeq

NP_065168.2